• Program Information
• Letter of Intent Deadline:
  

  TBA (last known deadline was September 27, 2012)

• Program Description

  amfAR, The Foundation for AIDS Research, is pleased to announce the availability of targeted support for biomedical research projects relevant to exploring the mechanisms for HIV persistence and the potential for HIV eradication.
  
  This RFP solicits proposals relevant to exploring the mechanisms for HIV persistence and the potential for HIV eradication. Highly active antiretroviral therapy (HAART) has significantly impacted the health of individuals infected with HIV-1. However, if therapy is interrupted, there is a rapid resumption of viral replication. Understanding the mechanisms by which the virus is able to persist in the face of therapy is necessary in order to identify strategies that may interrupt viral persistence and ultimately lead to viral eradication. amfAR wishes to support basic, pre-clinical, clinical, and especially translational research exploring the mechanisms whereby HIV infection persists; the chronic nature of viral reservoirs and latency; and barriers to the eradication of HIV, with the potential goal of ultimately eliminating HIV infection.
  
  Specific areas of interest include:

  • Determine cellular and viral mechanisms that maintain HIV persistence
  • Determine the tissue and cellular sources of persistent HIV in long-term ART-treated individuals
  • Determine the origins of immune activation and inflammation in the presence of ART and their consequences for HIV persistence
  • Determine host and immune mechanisms that control infection but allow viral persistence
  • Study, compare, and validate assays to measure persistent infection
  • Develop and test therapeutic agents or immunological strategies to safely eliminate latent infection in individuals on ART
  • Develop and test strategies to enhance the capacity of the host response to control active viral replication

• Other opportunities from amfAR Foundation for AIDS Research

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